Tigecycline (Tygacil), a first-in-class glycylcycline expanded-spectrum antimicrobial agent,(19) inhibits translation of bacterial proteins through its action on the 30S ribosomal subunit and circumvents resistance mechanisms
نویسندگان
چکیده
Scott Van Wart, M.S. Assistant Director, PK/PD Cognigen Corporation 395 Youngs Road Buffalo, NY 14221 (T): (716) 633-3463, ext. 241 (F): (716) 633-7404 Email: [email protected] AC CE PT ED Copyright © 2006, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved. Antimicrob. Agents Chemother. doi:10.1128/AAC.01636-05 AAC Accepts, published online ahead of print on 28 August 2006
منابع مشابه
Functional, biophysical, and structural bases for antibacterial activity of tigecycline.
Tigecycline is a novel glycylcycline antibiotic that possesses broad-spectrum activity against many clinically relevant species of bacterial pathogens. The mechanism of action of tigecycline was delineated using functional, biophysical, and molecular modeling experiments in this study. Functional assays showed that tigecycline specifically inhibits bacterial protein synthesis with potency 3- an...
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